Document Detail


Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I.
MedLine Citation:
PMID:  21880999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests a complex dysfunction of central motor-sensory circuits. The aim of our present study was to assess possible bilateral excitability changes in the somatosensory system of patients with CRPS.
METHODS: We measured paired-pulse suppression of somatosensory evoked potentials in 21 patients with unilateral CRPS I involving the hand. Eleven patients with upper limb pain of non-neuropathic origin and 21 healthy subjects served as controls. Innocuous paired-pulse stimulation of the median nerve was either performed at the affected and the unaffected hand, or at the dominant hand of healthy controls, respectively.
RESULTS: We found a significant reduction of paired-pulse suppression in both sides of patients with CRPS, compared with control patients and healthy control subjects.
CONCLUSION: These findings resemble our findings in the motor system and strongly support the hypothesis of a bilateral complex impairment of central motor-sensory circuits in CRPS I.
Authors:
M Lenz; O Höffken; P Stude; S Lissek; P Schwenkreis; A Reinersmann; J Frettlöh; H Richter; M Tegenthoff; C Maier
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-31
Journal Detail:
Title:  Neurology     Volume:  77     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-13     Completed Date:  2011-11-02     Revised Date:  2012-03-28    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1096-101     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. melanie.lenz@rub.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Electric Stimulation / methods
Evoked Potentials, Somatosensory / physiology*
Female
Humans
Male
Middle Aged
Neural Inhibition / physiology*
Reflex Sympathetic Dystrophy / diagnosis,  physiopathology*
Somatosensory Cortex / physiopathology*
Young Adult
Comments/Corrections
Comment In:
Neurology. 2012 Feb 21;78(8):606; author reply 606-7   [PMID:  22351800 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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