Document Detail

Bilateral skin conductance activity, clinical symptoms and CSF monoamine metabolite levels in unmedicated schizophrenics, differing in rate of habituation.
MedLine Citation:
PMID:  6204697     Owner:  NLM     Status:  MEDLINE    
Bilateral skin conductance (SC) and heart rate (HR) were recorded for 18 RDC-diagnosed unmedicated recently admitted psychotic patients (13 schizophrenic and 5 paranoid) and for age- and sex-matched controls, during rest and tone stimulation (85 dBA, 1000 Hz, 1 sec duration and 0.25 msec rise time). Schizophrenics had more SC spontaneous fluctuations and faster HR, indicating higher arousal. SC spontaneous fluctuations were more frequent in left hand and showed an increasing trend over the session. Several SC measures indicated higher responsivity and a more irregular responding pattern in schizophrenics. These patients had higher levels of the noradrenaline metabolite (MHPG). Paranoid psychotic patients had a more stable SC habituation course than controls, and higher levels of the dopamine (HVA) and serotonin metabolites (5-HIAA). Schizophrenic nonhabituators had fewer positive psychotic symptoms than habituators, suggesting that poor habituation is not due to interference by symptoms. It may be related to higher arousal, or to deficient information processing.
A Bartfai; G Edman; S E Levander; D Schalling; G Sedvall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychology     Volume:  18     ISSN:  0301-0511     ISO Abbreviation:  Biol Psychol     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-08-24     Completed Date:  1984-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375566     Medline TA:  Biol Psychol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-18     Citation Subset:  IM    
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MeSH Terms
Biogenic Amines / cerebrospinal fluid*
Galvanic Skin Response / physiology*
Habituation, Psychophysiologic / physiology*
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Paranoid Disorders / cerebrospinal fluid,  physiopathology*
Schizophrenia / cerebrospinal fluid,  physiopathology*
Reg. No./Substance:
0/Biogenic Amines; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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