| Bilateral progressive hearing loss and vestibular dysfunction with inner ear antibodies. | |
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MedLine Citation:
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PMID: 19709829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autoimmune inner ear disease (AIED) is a clinical syndrome of uncertain etiology. We present the neuro-otological findings of 2 cases of bilateral hearing loss, dizziness and the antibody profiles of the inner ears. Case 1 had bilateral progressive hearing loss, vestibular dysfunction and abnormal eye movement as the disease progressed. She had inner ear antibodies against 42 and 58kDa protein antigency on Western blot immune assay, and responded to glycocorticosteroid but not to immunosuppressant treatment. Intratympanic steroid injection temporally eliminated her symptoms. However, she developed idiopathic Cushing's syndrome and underwent labyrinthectomy. Case 2 became deaf as a teenager and experienced dizziness 10 years after becoming deaf. He reacted strongly to 68kDa protein and was a good responder to immunosuppressant with steroid. As we still lack a definitive diagnostic test for AIED, careful observation of the clinical course is critical for differential diagnosis regarding the bilateral progressive hearing loss. |
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Authors:
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Kumiko Yukawa; Akira Hagiwara; Yasuo Ogawa; Nobuhiro Nishiyama; Shigetaka Shimizu; Sachie Kawaguchi; Mari Nakamura; Hiroyuki Ito; Shunichi Tomiyama; Mamoru Suzuki |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-08-25 |
Journal Detail:
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Title: Auris, nasus, larynx Volume: 37 ISSN: 1879-1476 ISO Abbreviation: Auris Nasus Larynx Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708170 Medline TA: Auris Nasus Larynx Country: Netherlands |
Other Details:
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Languages: eng Pagination: 223-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.. |
Affiliation:
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Department of Otolaryngology, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, Japan. spicemomo@hotmail.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / administration & dosage, adverse effects Autoantibodies / blood* Autoimmune Diseases / diagnosis, drug therapy, immunology* Betamethasone / administration & dosage, adverse effects Combined Modality Therapy Cushing Syndrome / chemically induced Dose-Response Relationship, Drug Drug Administration Schedule Ear, Inner / immunology*, surgery Female Follow-Up Studies Gentamicins / administration & dosage Hearing Loss, Bilateral / diagnosis, drug therapy, immunology* Humans Immunosuppressive Agents / administration & dosage, adverse effects Male Prednisolone / administration & dosage, adverse effects Vestibular Diseases / diagnosis, drug therapy, immunology* Vestibular Function Tests Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Autoantibodies; 0/Gentamicins; 0/Immunosuppressive Agents; 378-44-9/Betamethasone; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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