Document Detail


Bilateral oophorectomy in a pregnant woman: hormonal profile from late gestation to post-partum: case report.
MedLine Citation:
PMID:  15528265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A 16 week pregnant woman presented with massive theca-lutein cysts requiring bilateral oophorectomy. Pregnancy progressed uneventfully and spontaneous lactation ensued after delivery. METHODS: To study the role of the ovary on the hormonal profile at the end of gestation and in post-partum, we measured FSH, estradiol (E2), unconjugated estrone (E1), unconjugated estriol (E3), sex hormone-binding globulin, progesterone, dehydroepiandrosterone sulphate and prolactin at 37 weeks gestation and at 8 h, 4 days, 5 weeks, and 2 months post-partum. RESULTS: These hormones were within the range expected for ovary-intact pregnant and puerperal women until 4 days post-partum. At 5 weeks post-partum, FSH increased to a peri-menopausal range (31.4 IU/l) while estrogens remained within the normal puerperal range (E2=239 pmol/l; E1=102 pmol/l), contrasting with their rapid changes in non-pregnant women after bilateral oophorectomy. At 2 months, while partially breastfeeding, FSH, E2 and E1 were closer to menopausal range (68 IU/l, 136 and 70.2 pmol/l respectively), and hormone replacement was started. CONCLUSIONS: We conclude that the ovary is not required to maintain a normal hormonal profile in late pregnancy and early puerperium. However, the increase in FSH to peri-menopausal levels at 5 weeks post-partum, despite breastfeeding, suggests that the ovary is needed to maintain low FSH concentrations during lactation.
Authors:
Paulina Villaseca; Carmen Campino; Eveline Oestreicher; David Mayerson; María Serón-Ferré; Eugenio Arteaga
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-04
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  20     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
Affiliation:
Department of Endocrinología, Facultad de Medicina, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. pvillase@med.puc.cl
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MeSH Terms
Descriptor/Qualifier:
Adult
Dehydroepiandrosterone Sulfate / blood
Estradiol / blood
Estriol / blood
Estrone / blood
Female
Follicle Stimulating Hormone / blood
Gonadal Steroid Hormones / blood*
Humans
Lactation / blood
Ovarian Cysts / blood,  surgery*
Ovariectomy*
Postpartum Period
Pregnancy
Pregnancy Complications / blood,  surgery*
Pregnancy Trimester, Third / blood
Progesterone / blood
Prolactin / blood
Sex Hormone-Binding Globulin / metabolism
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Sex Hormone-Binding Globulin; 50-27-1/Estriol; 50-28-2/Estradiol; 53-16-7/Estrone; 57-83-0/Progesterone; 651-48-9/Dehydroepiandrosterone Sulfate; 9002-62-4/Prolactin; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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