Document Detail


Bilateral oblique facial clefts and extremity anomaly in an infant after intrauterine efavirenz exposure and review of its teratogenic risk.
MedLine Citation:
PMID:  22695300     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Congenital anomalies may be caused by genetic or environmental factors or a combination of both. Oblique facial clefts are very rare congenital deformities. The occurrence of facial clefts and an extremity anomaly suggests a common underlying cause. Lateral oro-ocular clefts do not occur along normal developmental planes and may be part of the amnion disruption complex sequence. Our objective was to report a case of this very event, which also followed an unusual intrauterine exposure and review the literature on the teratogenic risk of efavirenz.
STUDY DESIGN: We report a case of amniotic rupture sequence after fetal HIV and antiretroviral exposure.
RESULT: Teratogenic exposure has been rarely reported and never after antiretroviral exposure.
CONCLUSION: By reporting and registering more cases, we will be able to better assess the risks such medications pose to the developing fetus. The publication of a single case report has the potential to contribute to our knowledge of the significance of prenatal exposure to antiretrovirals and other medications for common HIV-associated disorders. It also generates a hypothesis that can be tested with further clinical data, animal models and epidemiologic studies.
Authors:
Alan L Shanske
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  AIDS (London, England)     Volume:  26     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-01-16     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1775-9     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*,  radiography,  surgery
Acquired Immunodeficiency Syndrome / drug therapy
Adult
Anti-HIV Agents / administration & dosage,  adverse effects*
Benzoxazines / administration & dosage,  adverse effects*
Child of Impaired Parents*
Cleft Palate / chemically induced*,  radiography,  surgery
Craniofacial Dysostosis / chemically induced*,  radiography,  surgery
Eye Abnormalities / chemically induced*,  radiography,  surgery
Female
Humans
Imaging, Three-Dimensional
Infant
Infant, Newborn
Maxillofacial Abnormalities / chemically induced*,  radiography,  surgery
Pregnancy
Prenatal Exposure Delayed Effects*
Teratogens*
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Benzoxazines; 0/Teratogens; JE6H2O27P8/efavirenz

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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