| Bilateral oblique facial clefts and extremity anomaly in an infant after intrauterine Efavirenz exposure and review of its teratogenic risk. | |
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MedLine Citation:
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PMID: 22695300 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: Congenital anomalies may be caused by genetic or environmental factors or a combination of both. Oblique facial clefts are very rare congenital deformities. The occurrence of facial clefts and an extremity anomaly suggests a common underlying etiology. Lateral oro-ocular clefts do not occur along normal developmental planes and may be part of the amnion disruption complex sequence. Our objective was to report a case of this very event which also followed an unusual intrauterine exposure and review the literature on the teratogenic risk of efavirenz. STUDY DESIGN:: We report a case of amniotic rupture sequence after fetal HIV and antiretroviral exposure. RESULT:: Teratogenic exposure has been rarely reported and never after antiretroviral exposure. CONCLUSION:: By reporting and registering more cases, we will be able to better assess the risks such medications pose to the developing fetus. The publication of a single case report has the potential to contribute to our knowledge of the significance of prenatal exposure to antiretrovirals and other medications for common HIV-associated disorders. It also generates a hypothesis that can be tested with further clinical data, animal models and epidemiologic studies. |
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Authors:
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Alan L Shanske |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-12 |
Journal Detail:
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Title: AIDS (London, England) Volume: - ISSN: 1473-5571 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center for Craniofacial Disorders, Children's Hospital at, Montefiore, Albert Einstein College of Medicine, Bronx, NY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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