| Bilateral non-simultaneous optic neuropathy and unilateral macular edema in a patient with POEMS syndrome. | |
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MedLine Citation:
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PMID: 19123170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report a case of bilateral non-simultaneous optic neuropathy and unilateral macular edema in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. METHODS: A 61-year-old man with POEMS syndrome had bilateral anterior optic neuropathy and unilateral macular edema. RESULTS: Visual field testing showed bilateral superior altitudinal field defect. Fluorescein angiography revealed unilateral pooling of fluid consistent with cystoid macular edema. Optical coherence tomography (OCT) showed bilateral loss of retinal nerve fiber layer thickness. The erythrocyte sedimentation rate and C-reactive protein values were normal. The serum vascular growth factor measurement was elevated. CONCLUSIONS: This is the first reported case of ophthalmoscopic, angiographic, and OCT evidence of non-simultaneous optic neuropathy and macular edema in this syndrome. The increased vascular permeability could explain all these factors. |
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Authors:
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C Gutierrez-Ortiz; M Castro-Rebollo; J Pareja; C Beckford; M Teus |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of ophthalmology Volume: 19 ISSN: 1120-6721 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-01-05 Completed Date: 2009-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 166-9 Citation Subset: IM |
Affiliation:
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Hospital Universitario Príncipe de Asturias, Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, Spain. consuelogutierre@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Capillary Permeability Fluorescein Angiography Functional Laterality Humans Laser Coagulation Macular Edema / diagnosis, drug therapy, etiology* Male Middle Aged Ophthalmoscopy Optic Nerve Diseases / diagnosis, drug therapy, etiology* POEMS Syndrome / complications*, diagnosis, drug therapy Perimetry Tomography, Optical Coherence Vascular Endothelial Growth Factor A / blood Visual Fields |
| Chemical | |
Reg. No./Substance:
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0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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