Document Detail


Bilateral hearing loss heralding sporadic creutzfeldt-jakob disease: a case report and literature review.
MedLine Citation:
PMID:  25122149     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To report a case of sporadic Creutzfeldt-Jakob disease (CJD) with bilateral hearing loss at onset and literature review of the scarce cases of CJD with similar audiologic manifestations at presentation.
CASE REPORT: A 67-yr-old man presented to the hospital for evaluation of rapid progression of behavioral decline, unsteady gait, and bilateral hearing loss. Three months before admission, he abruptly developed bilateral hypoacusis without associated tinnitus or vertigo. Shortly after, his family noted an ataxic gait and behavioral changes, for example, paranoid delusions. Initial workup, including a complete autoimmune panel and heavy metals, infectious, toxicology, and paraneoplastic panel (e.g., anti-Hu, anti-VGKC), was conducted. Electroencephalography revealed diffuse generalized slowing without periodic complexes. The presence of distortion product otoacoustic emissions bilaterally was consistent with normal cochlear function, suggesting a retrocochlear origin for symptoms of hearing loss. In the meantime, the patient developed startle myoclonus. The brain magnetic resonance imaging demonstrated asymmetric cortical ribbon along with T2 FLAIR signal hyperintensities of bilateral basal ganglia. Later on, the protein 14-3-3 in the cerebrospinal fluid came back positive, which supported the diagnosis of CJD. Only three cases of CJD with deafness at onset have been published: one sporadic, associated with symptoms suggestive of polyneuropathy; and the other two familial, with the E200K mutation. One presented with symptoms of polyneuropathy and the other with typical features.
CONCLUSION: This case illustrates the phenotypic variability of presentation of CJD in a patient with hearing loss as the initial manifestation. In patients with subacute bilateral hypoacusis and signs of dementia, the differential diagnosis of CJD must be taken into consideration.
Authors:
Richard Salazar; Mirela Cerghet; Virginia Ramachandran
Related Documents :
21842209 - Primary lymphoma of the cranial vault: case report and a systematic review of the liter...
20961729 - Surgical treatment of primary melanoma of the umbilicus with sentinel lymph node biopsy...
17883189 - Iatrogenic benign paroxysmal positional vertigo: review and personal experience in dent...
11233629 - First case of surgically corrected puberphonia.
3898309 - Infections caused by drechslera species: case report and review of the literature.
21719479 - Evaluating 'success' in programme budgeting and marginal analysis: a literature review.
2975579 - Occupational sensitization to epichlorohydrin and epoxy resin.
20571789 - Trichuriasis colitis detected by doppler sonography.
18611939 - Papillary adenocarcinoma of the thymus: case report and review of the literature.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  35     ISSN:  1537-4505     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-08-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1327-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Management of incus necrosis in revision stapedectomy using hydroxyapatite bone cement.
Next Document:  Gender Differences in Response to Tadalafil in Pulmonary Arterial Hypertension.