Document Detail


Bilateral comparison of generalized lichen planus treated with psoralens and ultraviolet A.
MedLine Citation:
PMID:  6736339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten patients with generalized lichen planus were treated with oral 8-methoxypsoralen photochemotherapy (PUVA) in a bilateral comparison study. Five patients (50%) cleared completely on both sides and required no maintenance treatment after a follow-up of up to 4 years. Three other patients (30%) improved at least 50% of their previous involvement. Most of the patients experienced symptomatic improvement of the treated side by the second week of the treatment. Two patients reacted adversely and exacerbated while receiving treatment to one side of the body. While preliminary, this bilateral comparison study demonstrates that PUVA is an effective therapy for generalized, symptomatic lichen planus and suggests that maintenance therapy might not be required once complete clearance is attained. Caution should be exercised, however, since some patients might develop an exacerbation of their disease with PUVA.
Authors:
E Gonzalez; K Momtaz-T; S Freedman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  10     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-20     Completed Date:  1984-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  958-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Follow-Up Studies
Humans
Lichen Planus / drug therapy*,  physiopathology
Male
Middle Aged
PUVA Therapy*
Photochemotherapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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