Document Detail

Bilateral basal ganglia-thalamic lesions subsequent to prolonged fetal bradycardia.
MedLine Citation:
PMID:  10854798     Owner:  NLM     Status:  MEDLINE    
We report two infants with bilateral basal ganglia-thalamic lesions subsequent to prolonged fetal bradycardia. Cardiotocogram revealed severe bradycardia lasting for more than 20 min in both. They demonstrated a significant encephalopathy, abnormal muscle tones and signs of brainstem injury. Clinical or electrical seizures were not observed in either of them. CT during early neonatal period demonstrated decreased tissue attenuation in basal ganglia and thalami in the absence of extensive cortical changes. Both of them developed severe mental retardation and quadriplegia. MRI in late infancy demonstrated abnormal high intensity areas in bilateral basal ganglia, thalami and around central sulci on T2-weighted image. Close correlation between prolonged fetal bradycardia and basal ganglia-thalamic lesion was suggested.
A Okumura; F Hayakawa; T Kato; K Kuno; K Watanabe
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Early human development     Volume:  58     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-03     Completed Date:  2000-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  111-8     Citation Subset:  IM    
Department of Pediatrics, Anjo Kosei Hospital, Anjo, Aichi, Japan.
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MeSH Terms
Basal Ganglia Diseases / etiology*
Bradycardia / complications*,  diagnosis
Evoked Potentials, Auditory, Brain Stem
Fetal Diseases / diagnosis*
Infant, Newborn
Magnetic Resonance Imaging
Mental Retardation / etiology
Quadriplegia / etiology
Thalamic Diseases / etiology*

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