Document Detail

Bilateral angle-closure glaucoma induced by trimetoprim and sulfamethoxazole combination: case report
MedLine Citation:
PMID:  17768563     Owner:  NLM     Status:  MEDLINE    
Sulfamethoxazole-trimethoprim (cotrimoxazole) is an antibiotic combination widely used for infections treatment and prophylaxis. These and others sulfonamides have been implicated in a rare syndrome of choroidal effusion with transient myopia and angle-closure glaucoma. Previous cases reported in literature evolved to complete resolution after drug withdrawal. In contrast, we describe a rare case in which a patient developed the syndrome while taking cotrimoxazole, but did not recover visual acuity. A 49-year-old man started Pneumocystis carini prophylaxis with cotrimoxazole; four days later, the patient presented severe ocular pain, hyperemia and chemosis. Intraocular pressure reached more than 50 mmHg in both eyes a 360 degrees choroidal effusion occurred. Medication was removed soon after the diagnosis was suspected and intraocular pressure decreased in four days. Even so total cataract and phthisis bulbi occurred in both eyes two months later. This would be the first case in the literature in which the outcome was unfavorable despite early diagnosis and withdrawal of the drug.
Viviane Souto Spadoni; Melissa Manfroi Dal Pizzol; Carlos Henrique Gervini Muniz; Jacobo Melamed; João Borges Fortes Filho
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Arquivos brasileiros de oftalmologia     Volume:  70     ISSN:  0004-2749     ISO Abbreviation:  Arq Bras Oftalmol     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-09-04     Completed Date:  2008-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400645     Medline TA:  Arq Bras Oftalmol     Country:  Brazil    
Other Details:
Languages:  por     Pagination:  517-20     Citation Subset:  IM    
Serviço de Oftalmologia, Hospital de Clínicas, Porto Alegre, RS, Brasil.
Vernacular Title:
Glaucoma bilateral por fechamento angular induzido por sulfametoxazol-trimetoprima: relato de caso.
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MeSH Terms
Anti-Infective Agents / adverse effects*
Glaucoma, Angle-Closure / chemically induced*,  diagnosis
Middle Aged
Trimethoprim-Sulfamethoxazole Combination / adverse effects*
Reg. No./Substance:
0/Anti-Infective Agents; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

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