Document Detail

Bilateral acute necrosis of the globi pallidi and rhabdomyolysis due to combined methadone and benzodiazepine toxicity.
MedLine Citation:
PMID:  23361067     Owner:  NLM     Status:  MEDLINE    
Methadone continues to be a widely used maintenance therapy for opiate dependence. However, methadone-related deaths have been reported frequently for over 4 decades now. Anoxic brain injury with pulmonary edema secondary to respiratory depression is the recognized mechanism of methadone death, although pathological intracranial findings are rarely described in methadone deaths. A selective area of brain injury has never been reported with methadone use. We present a case of a 23-year-old man who had acute necrosis of the bilateral globi pallidi in the brain and systemic rhabdomyolysis after ingesting methadone and nasally insufflating alprazolam. We also present a review of the literature on deaths following opioid use and associated brain injury.
Robert F Corliss; Rakesh Mandal; Benjamin J Soriano
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of forensic medicine and pathology     Volume:  34     ISSN:  1533-404X     ISO Abbreviation:  Am J Forensic Med Pathol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-13     Completed Date:  2013-08-30     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  8108948     Medline TA:  Am J Forensic Med Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine and Waisman Center, University of Wisconsin, Madison, WI 53792, USA.
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MeSH Terms
Administration, Intranasal
Alprazolam / administration & dosage,  adverse effects*
Brain / pathology
Forensic Pathology
Forensic Toxicology
Glasgow Coma Scale
Globus Pallidus / pathology*
Hypnotics and Sedatives / administration & dosage,  adverse effects*
Intracranial Hemorrhages / pathology
Kidney / pathology
Methadone / administration & dosage,  adverse effects*
Narcotics / administration & dosage,  adverse effects*
Neurons / pathology
Rhabdomyolysis / chemically induced*,  pathology
Substance-Related Disorders / complications
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Narcotics; 28981-97-7/Alprazolam; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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