Document Detail

Bilateral Acute Iris Transillumination Following Systemic Moxifloxacin for Respiratory Illness: Report of Two Cases and Review of the Literature.
MedLine Citation:
PMID:  22694259     Owner:  NLM     Status:  Publisher    
Purpose: To describe two cases of bilateral acute iris transillumination following systemic administration of moxifloxacin and review the literature. Methods: Review of clinical records, and review of the literature using the PubMed database. Results: A 75 year-old man and 33 year-old woman presented with bilateral conjunctival injection, photophobia, and atonic, distorted pupils. The symptoms began acutely following a respiratory illness, for which both were treated with moxifloxacin. Both patients demonstrated profound iris transillumination, sectoral posterior bowing of the iris, corneal endothelial pigment dusting, and trabecular meshwork hyperpigmentation. One patient had a cotton-wool spot. A literature review identified 59 previous reports in 5 publications, including 17 patients with no antecedent fluoroquinolone use. Conclusions: Increased awareness of this recently described clinical entity should lead to a decrease in unnecessary diagnostic evaluations. It is currently unclear whether this disease represents an adverse effect of fluoroquinolone use or a sequela of a systemic illness.
R Grant Morshedi; Daniel I Bettis; Majid Moshirfar; Albert T Vitale
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-13
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  -     ISSN:  1744-5078     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
John A. Moran Eye Center, University of Utah , Salt Lake City , Utah.
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