Document Detail


Bilateral 6-hydroxydopamine lesion in the dopaminergic A8 cell group produces long-lasting deficits in motor programming of cats.
MedLine Citation:
PMID:  9517819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of a small 6-hydroxydopamine lesion in the A8 cell group were studied in cats (N = 8) trained to walk on a treadmill. This setup allows the assessment of subtle changes in motor programming. The lesion produced long-lasting effects: (a) a decreased ability to switch arbitrarily motor patterns; (b) an increased ability to switch motor patterns with the help of stimuli provided by the apparatus; (c) alterations in the sequential patterning of motor behavior and in the kinetic melody of movements. It is suggested that the lesion produced a hypofunction of A9 cells that is compensated by a hyperfunction of A10 cells. It is concluded that subtle lesions in the A8 cell group produce long-lasting deficits in motor programming, implying that degeneration of this dopaminergic cell group may contribute to symptoms seen in Parkinson's disease.
Authors:
M P Arts; A R Cools
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  112     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-20     Completed Date:  1998-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  102-15     Citation Subset:  IM    
Affiliation:
Department of Psychoneuropharmacology, Graduate School of Pathophysiology of the Nervous System, University of Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Cats
Dominance, Cerebral / physiology*
Dopamine / physiology*
Kinesthesis / physiology
Locomotion / physiology*
Male
Motor Neurons / physiology*
Motor Skills / physiology
Neural Pathways / physiology
Orientation / physiology
Oxidopamine
Red Nucleus / physiology*
Substantia Nigra / physiology*
Ventral Tegmental Area / physiology*
Chemical
Reg. No./Substance:
1199-18-4/Oxidopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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