Document Detail

Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans.
MedLine Citation:
PMID:  17927749     Owner:  NLM     Status:  MEDLINE    
AIMS: To isolate and identify antioomycete substances from Fusarium oxysporum EF119 against Phytophthora infestans and to investigate their antimicrobial activities against various plant pathogenic bacteria, oomycetes and true fungi. METHODS AND RESULTS: Two antioomycete substances were isolated from liquid cultures of F. oxysporum EF119, which shows a potent disease control efficacy against tomato late blight caused by P. infestans. They were identified as bikaverin and fusaric acid by mass and nuclear magnetic resonance spectral analyses. They inhibited the mycelial growth of plant pathogenic oomycetes and fungi. Fusaric acid also effectively suppressed the cell growth of various plant pathogenic bacteria, but bikaverin was virtually inactive. Treatment with bikaverin at 300 microg ml(-1) suppressed the development of tomato late blight by 71%. Fusaric acid provided effective control against tomato late blight and wheat leaf rust over 67% at concentrations more than 100 microg ml(-1). CONCLUSIONS: Both bikaverin and fusaric acid showed in vitro and in vivo antioomycete activity against P. infestans. SIGNIFICANCE AND IMPACT OF THE STUDY: Fusarium oxysporum EF119 producing both bikaverin and fusaric acid may be used as a biocontrol agent against tomato late blight caused by P. infestans.
S W Son; H Y Kim; G J Choi; H K Lim; K S Jang; S O Lee; S Lee; N D Sung; J-C Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-09
Journal Detail:
Title:  Journal of applied microbiology     Volume:  104     ISSN:  1365-2672     ISO Abbreviation:  J. Appl. Microbiol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-21     Completed Date:  2008-05-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  692-8     Citation Subset:  IM    
Bio-Control Research Team, Korea Research Institute of Chemical Technology, Yusong, Taejon, Korea.
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MeSH Terms
Capsicum / microbiology
Food Microbiology*
Fungicides, Industrial / pharmacology*
Fusaric Acid / chemistry,  pharmacology*
Fusarium / chemistry*
Phytophthora / drug effects*
Plant Extracts / pharmacology
Xanthones / chemistry,  pharmacology*
Reg. No./Substance:
0/Fungicides, Industrial; 0/Plant Extracts; 0/Xanthones; 33390-21-5/bikaverin; 536-69-6/Fusaric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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