Document Detail


Bigger is better: maternal and neonatal predictors of hematopoietic potential of umbilical cord blood units.
MedLine Citation:
PMID:  11244432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Umbilical cord blood (CB) is a useful stem cell source for patients without matched family donors. CB banking is expensive, however, because only a small percentage of the cord units stored are used for transplantation. In this study, we determined whether maternal factors, such as race, age, and smoking status have an effect on laboratory parameters of hematopoietic potential, such as viability, cell counts, CD34+ cell counts, and CFU-GM. We studied the effect of neonatal characteristics such as birth order, birth weight, gestational age, and sex of the baby on the same laboratory parameters. Race and maternal age had no effect on these laboratory parameters. In multivariate analysis, babies of longer gestational age had higher cell counts, but lower CD34+ cell counts and CFU-GM. Bigger babies had higher cell counts, more CD34+ cells, and more CFU-GM. Women with fewer previous live births also produced cord units with higher cell counts, CFU-GM, and CD34+ cell counts. Specifically, each 500 g increase in birth weight contributed to a 28% increase in CD34+ cell counts, each week of gestation contributed to a 9% decrease in CD34+cell counts, and each previous birth contributed to a 17% decrease in CD34+ cell counts (all P < 0.05). These data may be used to select the optimal cord blood donors and allow CB banks efficient resource allocation.
Authors:
K K Ballen; M Wilson; J Wuu; A M Ceredona; C Hsieh; F M Stewart; M A Popovsky; P J Quesenberry
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  27     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-06-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-14     Citation Subset:  IM    
Affiliation:
University of Massachusetts Cancer Center, Worcester, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Antigens, CD34 / blood
Birth Order
Birth Weight
Blood Banks / methods
Blood Donors*
Blood Specimen Collection / methods,  standards
Female
Fetal Blood / cytology*
Gestational Age
Hematopoietic Stem Cells / cytology
Humans
Infant, Newborn
Male
Maternal Age
Multivariate Analysis
Smoking
Chemical
Reg. No./Substance:
0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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