Document Detail

Big brain, a Drosophila homologue of mammalian aquaporin, is regulated by the DRE/DREF system.
MedLine Citation:
PMID:  18760387     Owner:  NLM     Status:  MEDLINE    
Drosophila big brain (bib) encodes for a protein similar to members of the major intrinsic protein family, which includes the water- and ion-conducting aquaporin (AQP) channels. In mammals, AQP dysregulation has been implicated in a variety of diseases, including colorectal cancer and colonic injury. However, the regulatory mechanisms of AQP expression remain to be clearly elucidated. In this study, as we found a DREF binding site (DRE) in the 5'-flanking regions of both the Drosophila bib gene and the human AQP1 gene, we assessed the role of DREF in bib gene expression. DREF in Drosophila and humans has been demonstrated to function as a key transcriptional activator for cell proliferation-related genes. Herein, we demonstrate that the DRE is required for optimal promoter activity of Drosophila bib gene, particularly in the larval imaginal discs, which are actively proliferating tissues, as well as the adult hindgut. Our results may provide insight into the mechanisms inherent to the regulation of mammalian AQP genes.
Joung-Sun Park; Su-Ryun Kim; So-Young Park; Dong-Jin Yang; Shin-Hae Lee; Yoon-Jeong Choi; Moon-Kyoung Bae; Masamitsu Yamaguchi; Young-Shin Kim; Mi-Ae Yoo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-07
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1779     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  789-96     Citation Subset:  IM    
Department of Molecular Biology, College of Natural Science, Pusan National University, Busan 609-735, Republic of Korea.
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MeSH Terms
Animals, Genetically Modified
Aquaporin 1 / metabolism
Aquaporins / metabolism*
Cell Nucleus / metabolism
Drosophila Proteins / genetics*,  physiology*
Drosophila melanogaster
Gene Expression Regulation
Membrane Proteins / genetics*,  physiology*
Models, Biological
Mutagenesis, Site-Directed
Promoter Regions, Genetic
Transcription Factors / genetics,  physiology*
Water / chemistry
Reg. No./Substance:
0/AQP1 protein, human; 0/Aquaporins; 0/Dref protein, Drosophila; 0/Drosophila Proteins; 0/Ions; 0/Membrane Proteins; 0/Transcription Factors; 0/bib protein, Drosophila; 146410-94-8/Aquaporin 1; 7732-18-5/Water

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