Document Detail


Bifurcations: focal points of particle adhesion in microvascular networks.
MedLine Citation:
PMID:  21418388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Particle adhesion in vivo is dependent on the microcirculation environment, which features unique anatomical (bifurcations, tortuosity, cross-sectional changes) and physiological (complex hemodynamics) characteristics. The mechanisms behind these complex phenomena are not well understood. In this study, we used a recently developed in vitro model of microvascular networks, called SMN, for characterizing particle adhesion patterns in the microcirculation.
METHODS: SMNs were fabricated using soft-lithography processes followed by particle adhesion studies using avidin and biotin-conjugated microspheres. Particle adhesion patterns were subsequently analyzed using CFD-based modeling.
RESULTS: Experimental and modeling studies highlighted the complex and heterogeneous fluid flow patterns encountered by particles in microvascular networks resulting in significantly higher propensity of adhesion (>1.5×) near bifurcations compared with the branches of the microvascular networks.
CONCLUSION: Bifurcations are the focal points of particle adhesion in microvascular networks. Changing flow patterns and morphology near bifurcations are the primary factors controlling the preferential adhesion of functionalized particles in microvascular networks. SMNs provide an in vitro framework for understanding particle adhesion.
Authors:
Balabhaskar Prabhakarpandian; Yi Wang; Angela Rea-Ramsey; Shivshankar Sundaram; Mohammad F Kiani; Kapil Pant
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  18     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-01     Completed Date:  2011-10-24     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380-9     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons Ltd.
Affiliation:
Biomedical Technology, CFD Research Corporation, Huntsville, Alabama, USA. bxp@cfdrc.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Avidin / chemistry
Biotin / chemistry
Cell Adhesion / physiology
Humans
Microspheres*
Microvessels / anatomy & histology,  physiology*
Models, Cardiovascular*
Grant Support
ID/Acronym/Agency:
2R44HL076034-03/HL/NHLBI NIH HHS; R44 HL076034-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
1405-69-2/Avidin; 58-85-5/Biotin
Comments/Corrections

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