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Bifocal Presentation of Primary Testicular Extranasal NK/T-Cell Lymphoma: A Case Report and Review of the Literature.
MedLine Citation:
PMID:  23997969     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Introduction. Testicular lymphoma is an aggressive disease with a very poor prognosis. Nasal-type natural killer/T-cell lymphoma (NKTCL-N) in particular is very uncommon and has a rapidly progressive, fatal course. Case Report. We report a case of primary NKTCL-N of the testis in a 38-years-old Middle Eastern man. The patient had a history of primary right testicular tumor diagnosed at an outside institution as a seminoma and treated with orchiectomy followed by chemo/radiation. On admission, the patient had an enormous nasal granuloma with blood workup showing pancytopenia and elevated liver function tests due to active hepatitis B infection. CT scan of the sinuses showed a very large soft tissue mass, and PET scan showed splenomegaly with multiple lymph node masses in the pelvis and the chest areas. Bone marrow and nasal tumor biopsies as well as review of the slides from the initial orchiectomy were all in favor of NKTCL-N lymphoma. The patient was treated with CHOD based combination chemotherapy and responded dramatically to the first two cycles but passed away from fulminant hepatitis B infection. Conclusion. Despite all known treatments of NKTCL-N lymphoma of the testes, this disease has a very poor prognosis and invariably follows an aggressive clinical course.
Authors:
Ali Naboush; Firas Farhat; Selim M Nasser; Francois G Kamar
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Publication Detail:
Type:  Journal Article     Date:  2013-08-12
Journal Detail:
Title:  Case reports in oncological medicine     Volume:  2013     ISSN:  2090-6706     ISO Abbreviation:  Case Rep Oncol Med     Publication Date:  2013  
Date Detail:
Created Date:  2013-09-02     Completed Date:  2013-09-02     Revised Date:  2013-09-04    
Medline Journal Info:
Nlm Unique ID:  101581035     Medline TA:  Case Rep Oncol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267389     Citation Subset:  -    
Affiliation:
Staten Island University Hospital, NY, USA.
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