Document Detail


Bifacial nucleoside as a surrogate for both T and A in duplex DNA.
MedLine Citation:
PMID:  21495708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new functional bifacial nucleoside derived from 7-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, a Janus-type nucleobase, has been synthesized and incorporated into DNA oligonucleotides. The nucleobase, having self-complementary H-bonding faces, mimics both T and A and engages in the corresponding Watson-Crick-like base pairs, forming stable duplexes.
Authors:
Dongwon Shin; Yitzhak Tor
Related Documents :
21347398 - Rna and dna bacteriophages as molecular diagnosis controls in clinical virology: a comp...
21401108 - Epiallele quantification using molecular inversion probes.
21425848 - Binary heterogeneous superlattices assembled from quantum dots and gold nanoparticles w...
21366598 - A simple dna characterization method using fiber-fluorescence in situ hybridization per...
3906388 - Induction of specific base-pair substitutions in e. coli trpa mutants by chloroethylene...
8953528 - Pcr detection of acute ehrlichia canis infection in dogs.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-15
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  133     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-04     Completed Date:  2011-08-25     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6926-9     Citation Subset:  IM    
Copyright Information:
© 2011 American Chemical Society
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine / chemistry*
Base Pairing*
DNA / chemistry*
Hydrogen Bonding
Molecular Mimicry*
Nucleosides / chemical synthesis,  chemistry*
Oligodeoxyribonucleotides / chemistry
Pyrimidinones / chemistry*
Thermodynamics
Thymidine / chemistry*
Grant Support
ID/Acronym/Agency:
GM 069773/GM/NIGMS NIH HHS; R01 GM069773/GM/NIGMS NIH HHS; R01 GM069773-08/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/7-aminopyrimido(4,5-d)pyrimidine-2,4(1H,3H)-dione; 0/Nucleosides; 0/Oligodeoxyribonucleotides; 0/Pyrimidinones; 9007-49-2/DNA; K72T3FS567/Adenosine; VC2W18DGKR/Thymidine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Zinc(II) and PPi Selective Fluorescence OFF-ON-OFF Functionality of a Chemosensor in Physiological C...
Next Document:  Methylation Stabilizes the Imino Tautomer of dAMP and Amino Tautomer of dCMP in Solution.