Document Detail


Bidirectional transport along microtubules.
MedLine Citation:
PMID:  15242636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Active transport by microtubule motors has a plethora of crucial roles in eukaryotic cells. Organelles often move bidirectionally, employing both plus-end and minus-end directed motors. Bidirectional motion is widespread and may allow dynamic regulation, error correction and the establishment of polarized organelle distributions. Emerging evidence suggests that motors for both directions are simultaneously present on cellular 'cargo', but that their activity is coordinated so that when plus-end motors are active, minus-end motors are not, and vice versa. Both the dynein cofactor dynactin and the Klarsicht (Klar) protein appear to be important for such coordination. The direction of net transport depends on the balance between plus-end directed and minus-end directed motion. In several model systems, factors crucial for setting this balance have now been identified, setting the stage for a molecular dissection of the underlying regulatory mechanisms. These analyses will likely provide insight into motor cooperation in general.
Authors:
Michael A Welte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current biology : CB     Volume:  14     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-09     Completed Date:  2004-10-05     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  R525-37     Citation Subset:  IM    
Affiliation:
Rosenstiel Biomedical Research Center and Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. welte@brandeis.edu
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MeSH Terms
Descriptor/Qualifier:
Biological Transport, Active
Drosophila Proteins / metabolism
Lipid Metabolism
Membrane Transport Proteins / metabolism
Microtubule-Associated Proteins / metabolism
Microtubules / metabolism*,  physiology
Mitochondria / metabolism
Models, Biological*
Molecular Motor Proteins / metabolism*,  physiology
Pigments, Biological / metabolism
Viruses / metabolism
Grant Support
ID/Acronym/Agency:
R01 GM064687/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Membrane Transport Proteins; 0/Microtubule-Associated Proteins; 0/Molecular Motor Proteins; 0/Pigments, Biological; 0/klar protein, Drosophila; 144198-36-7/dynactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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