| Bidirectional regulation of cAMP generating system by dopamine-D1 and D2-receptors in the rat retina. | |
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MedLine Citation:
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PMID: 1697754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulation or inhibition of cAMP formation in response to dopamine or dopamine related drugs in the absence or in the presence of forskolin and/or IBMX was investigated in isolated rat retina. While the existence of D1-receptors (positively coupled with adenylate cyclase) was confirmed, D2-receptors (negatively coupled to adenylate cyclase) were also revealed by using a selective D1-antagonist (SCH 23390), a D2-agonist (LY 171555) or two D2-antagonists (S-sulpiride, spiroperidol). These results indicate that rat retina may be used for the study of both types of dopamine-receptors. |
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Authors:
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J Z Nowak; B Sek; M Schorderet |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neural transmission. General section Volume: 81 ISSN: 0300-9564 ISO Abbreviation: J. Neural Transm. Gen. Sect. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-10-12 Completed Date: 1990-10-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9002201 Medline TA: J Neural Transm Gen Sect Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 235-40 Citation Subset: IM |
Affiliation:
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Department of Biogenic Amines, Polish Academy of Sciences, Lodz. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-3-isobutylxanthine
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pharmacology Animals Benzazepines / pharmacology Cyclic AMP / metabolism* Ergolines / pharmacology Forskolin / pharmacology Male Quinpirole Rats Rats, Inbred Strains Receptors, Dopamine / drug effects, physiology* Retina / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Ergolines; 0/Receptors, Dopamine; 28822-58-4/1-Methyl-3-isobutylxanthine; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 85760-74-3/Quinpirole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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