| Bidirectional function of coronary collateral channels in conscious dogs. | |
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MedLine Citation:
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PMID: 2054831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: The aim was to investigate the bidirectional functional adequacy of collateral perfusion in conscious dogs. DESIGN: Left circumflex coronary artery (LCCA) occlusions of 1 or 2 min duration were repeated to stimulate the development of collateral perfusion to the LCCA area, and the left anterior descending coronary artery (LAD) was occluded once daily to evaluate the development of retrograde LCCA-LAD flow. SUBJECTS: 7 male mongrel dogs were used, weight 25-28 kg. MEASUREMENTS AND MAIN RESULTS: Coronary collateral flow from the LCCA to the LAD perfusion area was measured as the abrupt decrease in the LCCA flow (implanted Doppler transducer) upon release of a brief LAD occlusion. Measurements were repeated daily during the development of collaterals induced by repeated, brief occlusions of the LCCA. After 35(SD17) days of such occlusions; there was no sustained reduction in LCCA regional myocardial function during an LCCA occlusion, and reactive hyperaemic repayment following the occlusion was negligible. Before and after collateral development, the LCCA to LAD collateral flow increased from 1.1(0.2) to 8.6(5.1) cm.s-1. LAD systolic segment shortening during the LAD occlusion increased from 2.1(2.0)% (first occlusion) to 19.3(8.6)% (last occlusion). CONCLUSIONS: LAD to LCCA collaterals serve as functionally significant bidirectional perfusion conduits, and monitoring of collateral perfusion development is practical by measuring the step reduction in LCCA flow upon abrupt release of an LAD occlusion. |
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Authors:
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M Fujita; D P McKown; M D McKown; D Franklin |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cardiovascular research Volume: 25 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-08-01 Completed Date: 1991-08-01 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 58-67 Citation Subset: IM |
Affiliation:
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Dalton Research Center, University of Missouri-Columbia, MO 65211. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Collateral Circulation / physiology* Coronary Circulation / physiology* Coronary Disease / etiology, physiopathology Dogs Heart Rate Male Myocardial Reperfusion |
| Grant Support | |
ID/Acronym/Agency:
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HL 32800/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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