| Bidirectional extracellular matrix signaling during tissue morphogenesis. | |
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MedLine Citation:
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PMID: 19896886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal tissue development and function are regulated by the interplay between cells and their surrounding extracellular matrix (ECM). The ECM provides biochemical and mechanical contextual information that is conveyed from the cell membrane through the cytoskeleton to the nucleus to direct cell phenotype. Cells, in turn, remodel the ECM and thereby sculpt their local microenvironment. Here we review the mechanisms by which cells interact with, respond to, and influence the ECM, with particular emphasis placed on the role of this bidirectional communication during tissue morphogenesis. We also discuss the implications for successful engineering of functional tissues ex vivo. |
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Authors:
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Nikolce Gjorevski; Celeste M Nelson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-11-06 |
Journal Detail:
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Title: Cytokine & growth factor reviews Volume: 20 ISSN: 1879-0305 ISO Abbreviation: Cytokine Growth Factor Rev. Publication Date: 2009 Oct-Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-03-04 Revised Date: 2012-03-15 |
Medline Journal Info:
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Nlm Unique ID: 9612306 Medline TA: Cytokine Growth Factor Rev Country: England |
Other Details:
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Languages: eng Pagination: 459-65 Citation Subset: IM |
Affiliation:
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Departments of Chemical Engineering & Molecular Biology, Princeton University, A321 Engineering Quadrangle, Princeton, NJ 08544, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Cell Proliferation Extracellular Matrix / metabolism, physiology* Humans Mechanotransduction, Cellular / physiology Models, Biological Morphogenesis / physiology* Signal Transduction / physiology* Tissue Engineering / methods |
| Grant Support | |
ID/Acronym/Agency:
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CA128660/CA/NCI NIH HHS; GM083997/GM/NIGMS NIH HHS; R01 GM083997-01/GM/NIGMS NIH HHS; R01 GM083997-05/GM/NIGMS NIH HHS; R21 CA128660-01/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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