Document Detail


Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence.
MedLine Citation:
PMID:  20555408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Female fertility is determined to a large extent by the quality (developmental competence) of the oocyte as reflected in its ability to undergo meiosis, be fertilized, and give rise to a healthy embryo. Growth of the mammalian oocyte is coordinated with that of the follicle that encloses it by the actions of signals that pass in both directions between the germline and somatic components. This review summarizes what is known about the roles played by 2 different modes of intrafollicular signalling in oogenesis: paracrine factors activating receptors on the opposite cell type, and direct sharing of small molecules throughout the follicle via gap junction channels. Recent evidence indicates that these 2 modes of signalling interact to regulate oocyte growth and granulosa cell proliferation and that defects in either can contribute to female infertility.
Authors:
Gerald M Kidder; Barbara C Vanderhyden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  88     ISSN:  1205-7541     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-06-17     Completed Date:  2010-10-12     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  399-413     Citation Subset:  IM    
Affiliation:
Departments of Physiology and Pharmacology, Obstetrics and Gynaecology, and Paediatrics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada. gerald.kidder@schulich.uwo.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication / physiology*
Cell Proliferation
Female
Fertility / physiology
Gap Junctions / physiology
Granulosa Cells / physiology*
Humans
Male
Oocytes / physiology*
Oogenesis / physiology*
Ovarian Follicle / physiology*
Paracrine Communication
Signal Transduction
Grant Support
ID/Acronym/Agency:
14150//Canadian Institutes of Health Research; //Canadian Institutes of Health Research
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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