Document Detail


Bidirectional augmentation of heart rate regulation by autonomic nervous system in rabbits.
MedLine Citation:
PMID:  8760187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the characteristics of the static interaction between the sympathetic and parasympathetic nervous systems in regulating heart rate (HR) have been well established, how the dynamic interaction modulates the HR response remains unknown. We therefore investigated dynamic interaction by estimating the transfer function from nerve stimulation to HR using a band-limited Gaussian white-noise technique. The transfer function relating dynamic sympathetic stimulation to HR had characteristics of a second-order low-pass filter. Simultaneous tonic vagal stimulation at 5 and 10 Hz increased gain of the transfer function by 55.0 +/- 40.1 and 80.7 +/- 50.5%, respectively (P < 0.05). The transfer function from dynamic vagal stimulation to HR had characteristics of a first-order low-pass filter. Simultaneous tonic sympathetic stimulation at 5 and 10 Hz increased the gain by 18.2 +/- 17.9 and 24.1 +/- 18.0%, respectively (P < 0.05). Thus interaction augmented dynamic gain bidirectionally, even though it affected mean HR antagonistically. By virtue of this interaction, the autonomic nervous system appears to extend its dynamic range of operation.
Authors:
T Kawada; Y Ikeda; M Sugimachi; T Shishido; O Kawaguchi; T Yamazaki; J Alexander; K Sunagawa
Related Documents :
15887537 - Orthonormal-basis partitioning and time-frequency representation of cardiac rhythm dyna...
22057 - Significance of oscillation frequency in intrapartum fetal monitoring.
17946767 - Frequency modulation between low- and high-frequency components of the heart rate varia...
7845397 - Factors influencing the amplitude and frequency of essential tremor.
23262727 - Multi-gigahertz frequency comb-based interferometry using frequency-variable superconti...
18835487 - Cononsolvency-induced micellization kinetics of pyrene end-labeled diblock copolymer of...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-10-08     Completed Date:  1996-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H288-95     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / physiology*
Electric Stimulation
Heart Rate / physiology*
Models, Cardiovascular
Rabbits
Sympathetic Nervous System / physiology
Vagus Nerve / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Encapsulation of VIP into liposomes restores vasorelaxation in hypertension in situ.
Next Document:  Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs.