Document Detail

Bidirectional augmentation of heart rate regulation by autonomic nervous system in rabbits.
MedLine Citation:
PMID:  8760187     Owner:  NLM     Status:  MEDLINE    
Although the characteristics of the static interaction between the sympathetic and parasympathetic nervous systems in regulating heart rate (HR) have been well established, how the dynamic interaction modulates the HR response remains unknown. We therefore investigated dynamic interaction by estimating the transfer function from nerve stimulation to HR using a band-limited Gaussian white-noise technique. The transfer function relating dynamic sympathetic stimulation to HR had characteristics of a second-order low-pass filter. Simultaneous tonic vagal stimulation at 5 and 10 Hz increased gain of the transfer function by 55.0 +/- 40.1 and 80.7 +/- 50.5%, respectively (P < 0.05). The transfer function from dynamic vagal stimulation to HR had characteristics of a first-order low-pass filter. Simultaneous tonic sympathetic stimulation at 5 and 10 Hz increased the gain by 18.2 +/- 17.9 and 24.1 +/- 18.0%, respectively (P < 0.05). Thus interaction augmented dynamic gain bidirectionally, even though it affected mean HR antagonistically. By virtue of this interaction, the autonomic nervous system appears to extend its dynamic range of operation.
T Kawada; Y Ikeda; M Sugimachi; T Shishido; O Kawaguchi; T Yamazaki; J Alexander; K Sunagawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-10-08     Completed Date:  1996-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H288-95     Citation Subset:  IM    
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan.
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MeSH Terms
Autonomic Nervous System / physiology*
Electric Stimulation
Heart Rate / physiology*
Models, Cardiovascular
Sympathetic Nervous System / physiology
Vagus Nerve / physiology

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