| Bid stands at the crossroad of stress-response pathways. | |
| | |
MedLine Citation:
|
PMID: 20482490 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Bid, a BH3-only Bcl-2 family member, is proven to be a pivotal molecule for the regulation of tumorigenesis by its multiple functions in promoting apoptosis, survival and proliferation. Growing evidence supports that Bid has double roles with respect to stress-response. In most cases it functions in a truncated form, but the cleavage of Bid may not be an absolute requirement for Bid to be pro-apoptotic. Full-length Bid can also translocate to and activate the mitochondria without cleavage. Bid has emerged as a central player linking death signals through surface death receptors to the core apoptotic mitochondrial pathway. Bid is also involved in DNA damage response, and the phosphorylated Bid may negatively regulate its pro-apoptotic function independent of the BH3 domain. This review surveys recent developments in understanding the molecular mechanisms of Bid activation and its roles in regulating the cross-talk of cell cycle arrest and apoptosis. |
| | |
Authors:
|
G Song; G G Chen; T Hu; P B S Lai |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Current cancer drug targets Volume: 10 ISSN: 1873-5576 ISO Abbreviation: Curr Cancer Drug Targets Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101094211 Medline TA: Curr Cancer Drug Targets Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 584-92 Citation Subset: IM |
Affiliation:
|
Cancer Research Center, Medical College, Xiamen University, Xiamen 361005, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targeting apoptotic signaling pathways in human lung cancer.
Next Document: Gabapentin for the treatment of cancer-related pain syndromes.