Document Detail


Bicuspid aortic valve disease: the role of oxidative stress in Lrp5 bone formation.
MedLine Citation:
PMID:  21257323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bicuspid aortic valve is a common congenital cardiac anomaly, having a prevalence of 0.9% to 1.37% in the general population and a male preponderance ratio of 2:1. The recognition of a bicuspid aortic valve is clinically relevant because of its association with aortic stenosis or regurgitation, aortic aneurysm or dissection, and infective endocarditis. Although some patients with a bicuspid aortic valve may go undetected without clinical complications for a lifetime, the vast majority will require intervention, most often surgery, at some point. In fact, the natural history of bicuspid aortic valve is that of valve calcification and progressive stenosis that typically occur at a faster rate than in tricuspid aortic valves. This pattern of presentation supports the hypothesis that shear stress in patients with congenitally abnormal aortic valves may contribute to an earlier leaflet calcification. However, there is emerging research data showing that the valve calcification process might have a similar pathophysiologic process to that of vascular atherosclerosis. This review focuses on the current knowledge of the cellular mechanisms of bicuspid aortic valve.
Authors:
Nalini M Rajamannan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-01-22
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  20     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-05-06     Completed Date:  2011-09-08     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  168-76     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Valve / abnormalities,  metabolism*,  physiopathology
Aortic Valve Stenosis / genetics,  metabolism*,  physiopathology
Calcinosis / genetics,  metabolism*,  physiopathology
Heart Defects, Congenital / genetics,  metabolism*,  physiopathology
Hemodynamics
Humans
LDL-Receptor Related Proteins / metabolism*
Low Density Lipoprotein Receptor-Related Protein-5
Nitric Oxide / metabolism
Nitric Oxide Synthase Type III / metabolism
Ossification, Heterotopic*
Oxidative Stress*
Receptor, Notch1 / metabolism
Signal Transduction
beta Catenin / metabolism
Grant Support
ID/Acronym/Agency:
1R01HL085591-01A1/HL/NHLBI NIH HHS; 5K08HL073927-04/HL/NHLBI NIH HHS; K08 HL073927/HL/NHLBI NIH HHS; K08 HL073927-04/HL/NHLBI NIH HHS; R01 HL085591/HL/NHLBI NIH HHS; R01 HL085591-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/LDL-Receptor Related Proteins; 0/LRP5 protein, human; 0/Low Density Lipoprotein Receptor-Related Protein-5; 0/NOTCH1 protein, human; 0/Receptor, Notch1; 0/beta Catenin; 31C4KY9ESH/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase Type III
Comments/Corrections

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