| Biclonal or biphenotypic Chronic Lymphotic Leukemia? An answer brought by the treatment. | |
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MedLine Citation:
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PMID: 21659049 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A 51-years-old patient with polyadenopathies presents a non monotypic chronic lymphocytic leukemia (CLL): lymphocytes B CD5+, CD23+, CD22-,CD79b dim, FMC7- express κ (71%) and λ (21%) light chains withoutcoexpression. The caryotype shows two clones with one in evolution. Lymphoid clonality analysis by PCR (polymerase chain reaction) of the heavy and light chains genes of immunoglobulins shows two monoclonal rearrangements for each kind of chains. Lack of lymphoid cells sorting in function of the light chain doesn't allow us to conclude between a biclonal CLL and a biallelic monoclonal CLL. New adenopathies appearance in this patient, one year and a half after the end of his chemotherapy, leads to realisation of a new immunophenotyping: CLL is now monotypic with κ light chains expressed at 95%. In the new caryotype, only one clone is still present: it is the clone in evolution in the first caryotype and which presents additional abnormalities. This evolution allows us to assert the biclonality of the primitive CLL, the two clones evolving differently under treatment. In conclusion, the patient presented a biclonal CLL with one clone responding to treatment and the other one resistant. |
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Authors:
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Céline Acker; Anne Staal; Cédric Aumont; Jacqueline Didion; Véronique Dorvaux; Yves Rio; Véronique Latger-Cannard |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Annales de biologie clinique Volume: 69 ISSN: 0003-3898 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984690R Medline TA: Ann Biol Clin (Paris) Country: - |
Other Details:
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Languages: ENG Pagination: 325-330 Citation Subset: - |
Affiliation:
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Laboratoire d'hématologie, Hôpital de Metz, CHR Metz-Thionville. |
Vernacular Title:
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Leucémie lymphoïde chronique biclonale ou biphénotypique ? Une réponse par le traitement. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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