Document Detail

Bicarbonate infusion and pH clamp moderately reduce hyperventilation during ramp exercise in humans.
MedLine Citation:
PMID:  16959908     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that the decrease in plasma pH contributes to the hyperventilation observed in humans in response to exercise at high workloads, five healthy male subjects performed a ramp exercise [maximal workload: 352 W (SD 35)] in a control situation and when arterialized plasma pH was maintained at the resting level (pH clamp) by intravenous infusion of sodium bicarbonate [129 mmol (SD 23), beginning at 59% maximal workload (SD 5)]. Bicarbonate infusion did not modify O(2) consumption (Vo(2)) but significantly (P < 0.05) increased arterial Pco(2), plasma bicarbonate concentration, and respiratory exchange ratio (P < 0.05). At the three highest workloads, pulmonary ventilation (Ve) and Ve/Vo(2) were approximately 5-10% lower (P < 0.05) when bicarbonate was infused than in the control situation, and hyperventilation was reduced by 15-30%. These data suggest that the decrease in plasma pH is one of the factors that contribute to the hyperventilation observed at high workloads.
François Péronnet; Tim Meyer; Bernard Aguilaniu; Carl-Etienne Juneau; Oliver Faude; Wilfried Kindermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-07
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  102     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-03-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-8     Citation Subset:  IM    
Département de Kinésiologie, Université de Montréal, CP 6128, Centre Ville, Montréal, QC, Canada H3C3J7.
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MeSH Terms
Acid-Base Equilibrium / physiology
Bicarbonates / administration & dosage,  blood,  pharmacology*
Carbon Dioxide / blood
Exercise / physiology*
Hydrogen-Ion Concentration
Hyperventilation / physiopathology*
Infusions, Intravenous
Oxygen Consumption / drug effects,  physiology
Pulmonary Ventilation / drug effects,  physiology
Rest / physiology
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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