| Bicarbonate infusion and pH clamp moderately reduce hyperventilation during ramp exercise in humans. | |
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MedLine Citation:
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PMID: 16959908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that the decrease in plasma pH contributes to the hyperventilation observed in humans in response to exercise at high workloads, five healthy male subjects performed a ramp exercise [maximal workload: 352 W (SD 35)] in a control situation and when arterialized plasma pH was maintained at the resting level (pH clamp) by intravenous infusion of sodium bicarbonate [129 mmol (SD 23), beginning at 59% maximal workload (SD 5)]. Bicarbonate infusion did not modify O(2) consumption (Vo(2)) but significantly (P < 0.05) increased arterial Pco(2), plasma bicarbonate concentration, and respiratory exchange ratio (P < 0.05). At the three highest workloads, pulmonary ventilation (Ve) and Ve/Vo(2) were approximately 5-10% lower (P < 0.05) when bicarbonate was infused than in the control situation, and hyperventilation was reduced by 15-30%. These data suggest that the decrease in plasma pH is one of the factors that contribute to the hyperventilation observed at high workloads. |
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Authors:
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François Péronnet; Tim Meyer; Bernard Aguilaniu; Carl-Etienne Juneau; Oliver Faude; Wilfried Kindermann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-07 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 102 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-08 Completed Date: 2007-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 426-8 Citation Subset: IM |
Affiliation:
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Département de Kinésiologie, Université de Montréal, CP 6128, Centre Ville, Montréal, QC, Canada H3C3J7. francois.peronnet@umontreal.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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physiology Adult Bicarbonates / administration & dosage, blood, pharmacology* Carbon Dioxide / blood Exercise / physiology* Humans Hydrogen-Ion Concentration Hyperventilation / physiopathology* Infusions, Intravenous Male Oxygen Consumption / drug effects, physiology Pulmonary Ventilation / drug effects, physiology Rest / physiology |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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