Document Detail

Bicarbonate attenuates arterial desaturation during maximal exercise in humans.
MedLine Citation:
PMID:  12133884     Owner:  NLM     Status:  MEDLINE    
The contribution of pH to exercise-induced arterial O2 desaturation was evaluated by intravenous infusion of sodium bicarbonate (Bic, 1 M; 200-350 ml) or an equal volume of saline (Sal; 1 M) at a constant infusion rate during a "2,000-m" maximal ergometer row in five male oarsmen. Blood-gas variables were corrected to the increase in blood temperature from 36.5 +/- 0.3 to 38.9 +/- 0.1 degrees C (P < 0.05; means +/- SE), which was established in a pilot study. During Sal exercise, pH decreased from 7.42 +/- 0.01 at rest to 7.07 +/- 0.02 but only to 7.34 +/- 0.02 (P < 0.05) during the Bic trial. Arterial PO2 was reduced from 103.1 +/- 0.7 to 88.2 +/- 1.3 Torr during exercise with Sal, and this reduction was not significantly affected by Bic. Arterial O2 saturation was 97.5 +/- 0.2% at rest and decreased to 89.0 +/- 0.7% during Sal exercise but only to 94.1 +/- 1% with Bic (P < 0.05). Arterial PCO2 was not significantly changed from resting values in the last minute of Sal exercise, but in the Bic trial it increased from 40.5 +/- 0.5 to 45.9 +/- 2.0 Torr (P < 0.05). Pulmonary ventilation was lowered during exercise with Bic (155 +/- 14 vs. 142 +/- 13 l/min; P < 0.05), but the exercise-induced increase in the difference between the end-tidal O2 pressure and arterial PO2 was similar in the two trials. Also, pulmonary O2 uptake and changes in muscle oxygenation as determined by near-infrared spectrophotometry during exercise were similar. The enlarged blood-buffering capacity after infusion of Bic attenuated acidosis and in turn arterial desaturation during maximal exercise.
Henning B Nielsen; Per P Bredmose; Morten Strømstad; Stefanos Volianitis; Bjørn Quistorff; Niels H Secher
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  93     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-22     Completed Date:  2003-02-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  724-31     Citation Subset:  IM    
The Copenhagen Muscle Research Center, Department of Anesthesia, Rigshospitalet, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Acidosis / drug therapy,  physiopathology*
Carbon Dioxide / blood*
Heart Rate
Hydrogen-Ion Concentration
Lactic Acid / blood
Muscle, Skeletal / physiology
Oxygen / blood*
Physical Exertion / physiology*
Pulmonary Gas Exchange / physiology
Sodium Bicarbonate / administration & dosage*,  blood
Spectroscopy, Near-Infrared
Reg. No./Substance:
124-38-9/Carbon Dioxide; 144-55-8/Sodium Bicarbonate; 50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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