Document Detail


Biaxial mechanical properties of carotid arteries from normotensive and hypertensive rats.
MedLine Citation:
PMID:  7607718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is known to decrease arterial distensibility and volumetric compliance, as reported from pressure-volume experiments and ring and strip studies of human and animal large arteries. However, recent data using noninvasive in vivo recording of vessel diameter suggest that the cross-sectional compliance of large arteries can be unchanged or even increased in hypertensive subjects. The present study was performed to test the hypothesis that differences between volumetric and cross-sectional compliance could be related to differences in biaxial mechanical properties in normotensive and hypertensive rats. In normotensive (Wistar-Kyoto [WKY]) rats and spontaneously hypertensive rats (SHR) we measured the simultaneous changes in length and diameter of in situ isolated carotid arteries submitted to static pressures (50 to 200 mm Hg by steps of 25 mm Hg each). Carotid artery diameters and lengths were determined by video microscopy and computer-assisted image analysis. At low transmural pressure (50 mm Hg), carotid artery diameter was 710 +/- 41 microns in WKY rats and 980 +/- 31 microns in SHR (P < .01). In response to pressure increases, the carotid diameter increased by 91 +/- 6% in WKY rats and by 41 +/- 4% in SHR (P < .01). In parallel, the percent increase in carotid length was much larger in WKY rats than in SHR (31 +/- 2% versus 7 +/- 1%, respectively; P < .01). In WKY rats, longitudinal distensibility causes significantly larger volumetric values than cross-sectional compliance values; in contrast, because of the very small longitudinal distensibility, volumetric and cross-sectional compliances are almost identical in SHR.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
O Lichtenstein; M E Safar; P Poitevin; B I Levy
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  26     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-14     Completed Date:  1995-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Affiliation:
INSERM Unit 141, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Biomechanics
Blood Pressure
Carotid Arteries / anatomy & histology,  physiology*
Compliance
Elasticity
Hypertension / physiopathology*
Image Processing, Computer-Assisted
Microscopy, Video
Models, Biological
Rats
Rats, Inbred SHR
Rats, Inbred WKY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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