Document Detail

Biatrial substrate properties in patients with atrial fibrillation.
MedLine Citation:
PMID:  17764448     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The atrial substrate plays an important role in the maintenance of atrial fibrillation (AF). Further investigation of the biatrial substrate may be helpful for understanding the mechanism of AF. The aim of this study was to investigate the properties of right and left atrial (RA and LA) substrate in AF patients and their impact on the catheter ablation. METHODS: Biatrial electroanatomic mapping using a three-dimensional mapping system (NavX) was performed in 117 consecutive patients with paroxysmal (n = 99) and persistent (n = 18) AF. The biatrial voltage and total activation time (TAT) were obtained during sinus rhythm. RESULTS: The LA had a lower voltage (1.6 +/- 0.5 vs 2.0 +/- 0.6 mV, P < 0.001) than the RA. The TAT correlated with the voltage (r = -0.65, P < 0.001). The patients with persistent AF had a lower atrial voltage, higher coefficient of variance for the LA voltage, longer LA TAT, and more extensive scar than those with paroxysmal. The patients with recurrent AF after catheter ablation had a lower LA voltage and higher incidence of LA scarring than those without recurrence. A scar located in the low anteroseptal or low posterior wall of LA was related to recurrence of AF. LA scarring was the independent predictor of AF recurrence after catheter ablation. CONCLUSION: The LA voltage was lower than the RA, and the atrial voltage correlated with the TAT. Electroanatomical remodeling of the atria could be crucial to the maintenance of AF. The LA substrate properties may play an important role in the recurrence of AF after catheter ablation of AF.
Shih-Lin Chang; Ching-Tai Tai; Yenn-Jiang Lin; Wanwarang Wongcharoen; Li-Wei Lo; Ta-Chuan Tuan; Ameya R Udyavar; Sheng-Hsiung Chang; Hsuan-Ming Tsao; Ming-Hsiung Hsieh; Yu-Feng Hu; Yi-Jen Chen; Shih-Ann Chen
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Publication Detail:
Type:  Journal Article     Date:  2007-08-30
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  18     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1134-9     Citation Subset:  IM    
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taiwan.
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MeSH Terms
Atrial Fibrillation / physiopathology*,  surgery
Body Surface Potential Mapping
Catheter Ablation
Electrophysiologic Techniques, Cardiac / methods
Heart Conduction System / physiopathology*
Middle Aged
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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