Document Detail


Biaryl synthesis with control of axial chirality.
MedLine Citation:
PMID:  17036104     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Biaryls have been a persistent focus of interest for chemists since it was recognised, more than 80 years ago, that they can manifest the axial chirality that is inherent in structures consisting of intersecting dissymmetric planes. In recent decades their importance has risen steeply as this structural motif proved spectacularly successful in catalytic synthetic roles and was found to be significant in the context of biological activity. As a consequence, synthetic methods which allowed the construction of biaryls with axial stereocontrol have become highly desirable, and this article traces the development of non-resolution approaches to biaryls with a chosen axial configuration.
Authors:
Timothy W Wallace
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Publication Detail:
Type:  Journal Article     Date:  2006-08-01
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  4     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-10-12     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3197-210     Citation Subset:  -    
Affiliation:
School of Chemistry, University of Manchester, Oxford Road, Manchester, UKM13 9PL. tim.wallace@manchester.ac.uk
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