Document Detail

BiPAP in acute respiratory failure due to myasthenic crisis may prevent intubation.
MedLine Citation:
PMID:  12451217     Owner:  NLM     Status:  MEDLINE    
Noninvasive mechanical ventilation using bilevel positive pressure ventilation (BiPAP) has not been studied in acute respiratory failure caused by MG. Eleven episodes in nine patients were initially managed with BiPAP, and endotracheal intubation was avoided in seven of these trials. Presence of hypercapnia (PaCO2 greater than 50 mm Hg) at onset predicted BiPAP failure and subsequent intubation. Results of this preliminary study suggest that a trial of BiPAP may prevent intubation in patients with myasthenic crisis without overt hypercapnia.
Alejandro Rabinstein; Eelco F M Wijdicks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  59     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2002-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1647-9     Citation Subset:  AIM; IM    
Neurologic-Neurosurgical ICU, Saint Mary's Hospital, Mayo Medical Center, Rochester, MN 55905, USA.
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MeSH Terms
Acute Disease
Blood Gas Analysis
Hypercapnia / complications
Intubation, Intratracheal
Myasthenia Gravis / complications*
Point-of-Care Systems
Positive-Pressure Respiration*
Respiratory Function Tests
Respiratory Insufficiency / etiology*,  therapy*
Retrospective Studies
Comment In:
Neurology. 2003 Jul 8;61(1):144; author reply 144   [PMID:  12847184 ]

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