Document Detail

Bi-directional coupling between dihydropyridine receptors and ryanodine receptors.
MedLine Citation:
PMID:  11861208     Owner:  NLM     Status:  MEDLINE    
The control of calcium signaling between plasma membrane dihydropyridine receptors (DHPRs or L-type calcium channels) and ryanodine receptors (RyRs or calcium release channels) located in the endoplasmic/sarcoplasmic reticulum (ER/SR) underlies a broad array of functions including skeletal muscle contraction, cardiac performance, arteriole tone, neurosecretion, synaptic plasticity, and gene regulation. It has long been appreciated that DHPR activation of RyRs and subsequent calcium release from intracellular stores represents a key event in the control of these processes. In excitable cells, DHPRs trigger the release of intracellular calcium by promoting the opening of nearby RyRs (termed orthograde coupling). Interestingly, the signaling interaction between DHPRs and RyRs is often bi-directional such that the calcium-conducting activity of DHPR channels is also regulated by its interaction with the RyR (termed retrograde coupling). Recent data indicate that skeletal, cardiac, and neuronal cells utilize fundamentally distinct DHPR/RyR bi-directional coupling mechanisms (chemical and mechanical) in order to control the efficiency, fidelity, and activity of each of these two essential calcium channels. This review will focus on evaluating the nature and molecular determinants of these coupling mechanisms, as well as the extent to which excitable cell function is influenced by bi-directional DHPR/RyR calcium signaling.
Robert T Dirksen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2002-03-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  7     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-25     Completed Date:  2002-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  d659-70     Citation Subset:  IM    
University of Rochester School of Medicine and Dentistry, Rochester, NY 14534, USA.
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MeSH Terms
Calcium Channels, L-Type / chemistry,  metabolism*,  physiology
Neurons / chemistry,  physiology
Receptor Cross-Talk / physiology
Ryanodine Receptor Calcium Release Channel / chemistry,  metabolism*,  physiology
Grant Support
Reg. No./Substance:
0/Calcium Channels, L-Type; 0/Ryanodine Receptor Calcium Release Channel

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