| The Bezold-Jarisch reflex in acute inferior myocardial infarction: clinical and sympathovagal spectral correlates. | |
| | |
MedLine Citation:
|
PMID: 12862298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The cardiodepressor Bezold-Jarisch reflex (BJR) in acute inferior myocardial infarction (AMI) is traditionally considered as an indicator of successful thrombolysis. HYPOTHESIS: The study aim was to elucidate the role of the autonomic nervous system in the pathogenesis of a BJR response in patients with AMI by tracing spectral profiles of heart rate variability (HRV). METHODS: We studied 32 patients who presented with BJR after starting intravenous thrombolysis for an inferior AMI. Spectral components of HRV were analyzed over the three specific 5-min periods preceding and following reflex activation. Clinically, the occurrence of BJR was correlated with the outcome of thrombolysis to achieve timely reperfusion and sustained coronary artery patency. RESULTS: The BJR was associated with early reperfusion in 94% of the patients, and with benign transient bradyarrhythmias and patent Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow right coronary arteries in 89% of the patients. Spectral analysis revealed a characteristic pattern of a sympathetic predominance with an impending gradual vagal withdrawal up to the onset of BJR, as reflected by progressive increases in low-frequency and reciprocal changes in high-frequency powers. CONCLUSIONS: The BJR in inferior AMI represents a reliable prognosticator of timely reperfusion and sustained coronary patency. Stimulation of vagal afferents in response to sympathetic overactivity may be the underlying pathogenetic mechanism promoting a BJR response. |
| | |
Authors:
|
John A Chiladakis; Nikolaos Patsouras; Antonis S Manolis |
Related Documents
:
|
9049518 - Influence of residual ischaemia on heart rate variability after myocardial infarction. 11704478 - Analysis of sympathetic nerve activity in end-stage cardiomyopathy patients receiving l... 2410728 - Role of cardiac sympathetic nerves in the genesis of myocardial ischemia distal to coro... 696838 - Norepinephrine uptake as an indicator of cardiac reinnervation in dogs. 11240878 - Monitoring of pacemaker induced changes in cardiac output with inspired to endtidal oxy... 8250298 - Relation between oxygen consumption and oxygen delivery in patients after cardiac surgery. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical cardiology Volume: 26 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-07-16 Completed Date: 2003-11-04 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 323-8 Citation Subset: IM |
Affiliation:
|
Cardiology Department, Patras University Medical School, Rio, Patras, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Autonomic Nervous System / physiopathology* Blood Pressure / physiology* Electrocardiography Female Heart Rate / physiology* Humans Male Middle Aged Myocardial Infarction / physiopathology* Myocardial Revascularization Reflex / physiology* Sympathetic Nervous System / physiopathology Thrombolytic Therapy Vagus Nerve / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased TIMI frame counts in cocaine users: a case for increased microvascular resistance in the a...
Next Document: Intravenous amiodarone for cardioversion of recent-onset atrial fibrillation.