Document Detail


Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue.
MedLine Citation:
PMID:  11216866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats treated with bezafibrate, a PPAR activator, gain less body weight and increase daily food intake. Previously, we have related these changes to a shift of thermogenesis from brown adipose tissue to white adipose tissue attributable to bezafibrate, which induces uncoupling proteins (UCP), UCP-1 and UCP-3, in rat white adipocytes. Nevertheless, UCP induction was weak, implying additional mechanisms in the change of energy homeostasis produced by bezafibrate. Here we show that bezafibrate, in addition to inducing UCPs, modifies energy homeostasis by directly inducing aco gene expression and peroxisomal fatty acid beta-oxidation in white adipose tissue. Further, bezafibrate significantly reduced plasma triglyceride and leptin concentrations, without modifying the levels of PPARgamma or ob gene in white adipose tissue. These results indicate that bezafibrate reduces the amount of fatty acids available for triglyceride synthesis in white adipose tissue.
Authors:
M Vázquez; N Roglans; A Cabrero; C Rodríguez; T Adzet; M Alegret; R M Sánchez; J C Laguna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  216     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-16     Completed Date:  2001-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  71-8     Citation Subset:  IM    
Affiliation:
Departamento Farmacología y Química Terapéutica, Facultad de Farmacia, Núcleo Universitario de Pedralbes, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acyl-CoA Oxidase
Adipose Tissue / metabolism*
Animals
Antilipemic Agents / pharmacology*
Bezafibrate / pharmacology*
Body Weight / drug effects
Cells, Cultured
Cholesterol / blood
Fatty Acids / metabolism*
Leptin / blood
Liver / drug effects,  metabolism
Male
Oxidoreductases / metabolism*
Oxygen / metabolism*
Peroxisomes / metabolism*
RNA / metabolism
RNA, Messenger / metabolism
Rats
Rats, Sprague-Dawley
Receptors, Cytoplasmic and Nuclear / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Temperature
Time Factors
Transcription Factors / metabolism
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Fatty Acids; 0/Leptin; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 0/Triglycerides; 41859-67-0/Bezafibrate; 57-88-5/Cholesterol; 63231-63-0/RNA; 7782-44-7/Oxygen; EC 1.-/Oxidoreductases; EC 1.3.3.6/Acyl-CoA Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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