Document Detail

Bezafibrate-induced improvement in glucose uptake and endothelial function in protease inhibitor-associated insulin resistance.
MedLine Citation:
PMID:  12472919     Owner:  NLM     Status:  MEDLINE    
Protease inhibitors used as therapy for HIV-1 infection have been associated with metabolic side-effects such as peripheral fat wasting, central adiposity, hyperlipidaemia and insulin resistance. This metabolic disorder is known as the lipodystrophy syndrome. This syndrome can be recognized by the early appearance of an increase in serum triglyceride, cholesterol and plasma-free fatty acid levels. Here, we describe an HIV-1 positive patient with the lipodystrophy syndrome in whom a decline in serum triglycerides was seen along with a significant improvement in glucose uptake following treatment with bezafibrate for 3 months. This improvement may be a consequence of the Randle effect, i.e. increased availability of plasma-free fatty acids is negatively correlated to glucose uptake. We also noted a significant improvement in endothelial-dependent flow-mediated dilatation after treatment with bezafibrate. This effect could result from the increased glucose uptake observed and a decrease in insulin resistance secondary to the lowered triglyceride levels by bezafibrate. We conclude that bezafibrate may be of clinical utility in the lipodystrophy syndrome, through its beneficial effects on insulin resistance, glucose uptake and endothelial dysfunction.
T Nyström; G Bratt; A Sjöholm
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  252     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-10     Completed Date:  2003-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  570-4     Citation Subset:  IM    
Department of Internal Medicine, Karolinska Institutet, Stockholm South Hospital, Stockholm, Sweden.
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MeSH Terms
Antilipemic Agents / therapeutic use*
Bezafibrate / therapeutic use*
Blood Glucose / metabolism*
Brachial Artery / drug effects
Endothelium, Vascular
HIV-Associated Lipodystrophy Syndrome / drug therapy*,  metabolism
Insulin Resistance / physiology*
Vasodilation / drug effects
Reg. No./Substance:
0/Antilipemic Agents; 0/Blood Glucose; 41859-67-0/Bezafibrate

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