Document Detail


Bezafibrate Causes Depression of the Immune Response and Increases the Sensitivity to Endotoxin in Association with Low Level of HDL and PPARα Activity in Hypertensive ISIAH Rats.
MedLine Citation:
PMID:  24288751     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We studied the effect of bezafibrate on hepatic PPARα activity and immune parameters in hypertensive ISIAH rats in comparison with normotensive WAG rats under conditions of LPS treatment. Bezafibrate increased activity of PPARα in WAG rats, but not in ISIAH rats. As differentiated from WAG rats, bezafibrate produced a potent effect on the content of T cell subpopulations in the thymus and spleen of ISIAH rats. Administration of LPS after injection of bezafibrate caused death of 50% ISIAH animals (but not WAG rats), which was associated with low level of HDL cholesterol and increased triglyceride content. Our results suggest that the hypolipidemic treatment (e.g., bezafibrate) can increase the severity of complications in patients with infectious and inflammatory diseases in association with low level of HDL.
Authors:
A V Shurlygina; M I Dushkin; E V Mel'nikova; N G Panteleeva; M I Tenditnik; M V Khrapova; V A Trufakin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  155     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  724-8     Citation Subset:  IM    
Affiliation:
Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. anna_v_s@mail.ru.
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