Document Detail


Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system.
MedLine Citation:
PMID:  17150260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid by cytochrome P450 epoxygenases, are potent vasodilators that function as endothelium-derived hyperpolarizing factors in some vascular beds. EETs are rapidly metabolized by soluble epoxide hydrolase to form dihydroxyeicosatrienoic acids (DHETs). Recent reports indicate that EETs have several important non-vasomotor regulatory roles in the cardiovascular system. EETs are potent anti-inflammatory agents and might function as endogenous anti-atherogenic compounds. In addition, EETs and DHETs might stimulate lipid metabolism and regulate insulin sensitivity. Thus, pharmacological inhibition of soluble epoxide hydrolase might be useful not only for hypertension but also for abating atherosclerosis, diabetes mellitus and the metabolic syndrome. Finally, although usually protective in the systemic circulation, EETs might adversely affect the pulmonary circulation.
Authors:
Brandon T Larsen; William B Campbell; David D Gutterman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2006-12-05
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  28     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-03-22     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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MeSH Terms
Descriptor/Qualifier:
8,11,14-Eicosatrienoic Acid / analogs & derivatives*,  metabolism*
Animals
Arachidonic Acid / metabolism*,  pharmacology
Atherosclerosis / metabolism
Cardiovascular System / cytology,  metabolism*
Humans
Hypertension, Pulmonary / metabolism
Insulin Resistance
Metabolic Syndrome X / metabolism
Molecular Structure
Vasodilation / physiology*
Grant Support
ID/Acronym/Agency:
HL-51055/HL/NHLBI NIH HHS; HL-68769/HL/NHLBI NIH HHS; HL-83297/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
506-32-1/Arachidonic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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