| Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populations. | |
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MedLine Citation:
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PMID: 21365611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The thrifty genotype hypothesis initiated speculation that feast and famine cycling throughout history may have led to group-specific alterations of the human genome, thereby augmenting the capacity for excessive fat mass accrual when immersed in the modern-day obesogenic environment. Contemporary work, however, suggests alternative mechanisms influencing fuel utilization and subsequent tissue partitioning to be more relevant in the etiology of population-based variation in adipose storage. The objective of this study was to evaluate the independent and interactive contribution of ancestral admixture as a proxy for population-based genetic variation and diet on adipose tissue deposition and distribution in peripubertal children and to identify differences in racial/ethnic and sex groups. Two-hundred seventy-eight children (53% male) aged 7-12 years, categorized by parental self-report as African- (n = 91), European- (n = 110), or Hispanic American (n = 77), participated. Ancestral genetic admixture was estimated using 140 ancestry informative markers. Body composition was evaluated by dual-energy X-ray absorptiometry; energy expenditure by indirect calorimetry and accelerometry; and diet by 24-h-recall. Admixture independently contributed to all adiposity parameters; i.e., estimates of European and Amerindian ancestries were positively associated with all adiposity parameters, whereas African genetic admixture was inversely associated with adiposity. In boys, energy intake was associated with adiposity, irrespective of macronutrient profile, whereas in girls, the relationship was mediated by carbohydrate. We also observed moderating effects of energy balance/fuel utilization of the interaction between ancestral genetic admixture and diet. Interactive effects of genetic and non-genetic factors alter metabolic pathways and underlie some of the present population-based differences in fat storage. |
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Authors:
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Krista Casazza; Lynac J Hanks; T Mark Beasley; Jose R Fernandez |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-01 |
Journal Detail:
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Title: American journal of physical anthropology Volume: 145 ISSN: 1096-8644 ISO Abbreviation: Am. J. Phys. Anthropol. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-18 Completed Date: 2011-09-13 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0400654 Medline TA: Am J Phys Anthropol Country: United States |
Other Details:
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Languages: eng Pagination: 181-91 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-3360, USA. kristac@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adaptation, Physiological / physiology* Adipose Tissue / physiology* Analysis of Variance Body Fat Distribution / statistics & numerical data* Child Continental Population Groups Cross-Sectional Studies Diet / statistics & numerical data* Energy Intake / physiology Female Humans Linear Models Male Phenotype Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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K99 DK083333/DK/NIDDK NIH HHS; K99 DK083333-01/DK/NIDDK NIH HHS; M01 RR00032/RR/NCRR NIH HHS; R01 DK067426-01/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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