| Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. | |
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MedLine Citation:
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PMID: 23134607 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recent advancements in the periodontal research field are consistent with a new model of pathogenesis according to which periodontitis is initiated by a synergistic and dysbiotic microbial community rather than by select 'periopathogens', such as the 'red complex'. In this polymicrobial synergy, different members or specific gene combinations within the community fulfill distinct roles that converge to shape and stabilize a disease-provoking microbiota. One of the core requirements for a potentially pathogenic community to arise involves the capacity of certain species, termed 'keystone pathogens', to modulate the host response in ways that impair immune surveillance and tip the balance from homeostasis to dysbiosis. Keystone pathogens also elevate the virulence of the entire microbial community through interactive communication with accessory pathogens. Other important core functions for pathogenicity require the expression of diverse molecules (e.g. appropriate adhesins, cognate receptors, proteolytic enzymes and proinflammatory surface structures/ligands), which in combination act as community virulence factors to nutritionally sustain a heterotypic, compatible and proinflammatory microbial community that elicits a non-resolving and tissue-destructive host response. On the basis of the fundamental concepts underlying this model of periodontal pathogenesis, that is, polymicrobial synergy and dysbiosis, we term it the PSD model. |
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Authors:
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G Hajishengallis; R J Lamont |
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Publication Detail:
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Type: Journal Article Date: 2012-09-03 |
Journal Detail:
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Title: Molecular oral microbiology Volume: 27 ISSN: 2041-1014 ISO Abbreviation: Mol Oral Microbiol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101524770 Medline TA: Mol Oral Microbiol Country: Denmark |
Other Details:
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Languages: eng Pagination: 409-19 Citation Subset: D |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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