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Beyond nutrients: Food-derived microRNAs provide cross-kingdom regulation.
MedLine Citation:
PMID:  22354805     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Food turns out to be not only the nutrient supplier for our body but also a carrier of regulatory information. Interestingly, a recent study made the discovery that some plant/food-derived microRNAs (miRNAs) accumulate in the serum of humans or plant-feeding animals, and regulate mammalian gene expression in a sequence-specific manner. The authors provided striking evidence that miRNAs could function as active signaling molecules to transport information across distinct species or even kingdoms. Although the mechanism of how miRNAs are shuttled between different organisms is still not well characterized, initial results point to the involvement of microvesicles and specific RNA-transporter-like proteins. These findings raise both speculation about the potential impact that plants may have on animal physiology at the molecular level, and an appealing possibility that food-derived miRNAs may offer us another means to deliver necessary nutrients or therapeutics to our bodies.
Authors:
Mengxi Jiang; Xiaolin Sang; Zhi Hong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-22
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  -     ISSN:  1521-1878     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY Periodicals, Inc.
Affiliation:
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
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