| Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease. | |
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MedLine Citation:
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PMID: 22012750 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Deep brain stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The benefits of bilateral subthalamic stimulation are well documented, and some studies reported outcomes with a follow-up of 5 to 6 years; nevertheless, few data are available beyond 5 years. We report a long-term prospective evaluation of 14 consecutive parkinsonian patients, treated by bilateral subthalamic stimulation for at least 9 years. Motor symptoms, activity of daily living, and motor complications were evaluated by means of the Unified Parkinson's Disease Rating Scale, while cognition and mood were assessed with a specific neuropsychological test battery; medication intake, stimulation parameters, comorbidity, and adverse events were also recorded. Patients were evaluated before surgery and at 1, 5, and ≥9 years after surgery. At last follow-up, deep brain stimulation significantly improved the motor score by 42% compared to baseline, whereas activities of daily living were no longer improved; there was a 39% reduction in the dosage of dopaminergic drugs and a 59% improvement of L-dopa-related motor complications. The neuropsychological assessment showed that 4 patients (29%) developed a significant cognitive decline over the follow-up period. These results indicate a persistent effect of deep brain stimulation of the subthalamic nucleus on the cardinal motor symptoms in advanced Parkinson's disease patients in the long-term; however, a worsening of patients' disability, mainly due to disease progression, was observed. © 2011 Movement Disorder Society. |
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Authors:
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Maurizio Zibetti; Aristide Merola; Laura Rizzi; Valeria Ricchi; Serena Angrisano; Corrado Azzaro; Carlo Alberto Artusi; Nichy Arduino; Alice Marchisio; Michele Lanotte; Mario Rizzone; Leonardo Lopiano |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-25 |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: - ISSN: 1531-8257 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Movement Disorder Society. |
Affiliation:
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Department of Neuroscience, University of Torino, Torino, Italy. maurizio.zibetti@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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