Document Detail


Beyond islet transplantation in diabetes cell therapy: from embryonic stem cells to transdifferentiation of adult cells.
MedLine Citation:
PMID:  23769099     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allow tight regulation of glucose leading to long-term complications. Recently, pancreatic islet transplantation to reconstitute insulin-producing β cells, has emerged as an alternative promising therapeutic approach. Unfortunately, the number of donor islets is too low compared with the high number of patients needing a transplantation leading to a search for renewable sources of high-quality β-cells. This review, summarizes more recent promising approaches to the generation of new β-cells from embryonic stem cells for transdifferentiation of adult cells, particularly a critical examination of the seminal work by Lumelsky et al.
Authors:
M C Gioviale; M Bellavia; G Damiano; A I Lo Monte
Related Documents :
24782159 - Irf4 at the crossroads of effector t-cell fate decision.
24315439 - Functional repair of cftr by crispr/cas9 in intestinal stem cell organoids of cystic fi...
24147529 - A 3d in vitro model reveals differences in the astrocyte response elicited by potential...
23475869 - P110α contributes to p110δ inhibitor resistance.
23648269 - Characterization of ion currents of murine cd117(pos) stem cells in vitro and their mod...
15875519 - Stem cell therapy for cardiac arrhythmias.
7957829 - Alveolar macrophage-induced suppression of peripheral blood mononuclear cell responsive...
1988139 - Peripheral blood and bone marrow immunophenotypic and functional modifications induced ...
8618029 - Dermal mast cell activation by autoantibodies against the high affinity ige receptor in...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  45     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2019-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
Affiliation:
Transplant Unit, AOUP "P. Giaccone", School of Medicine, Università degli Studi di Palermo, Palermo, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Improved survival in patients with continuous-flow ventricular assist device for bridge to heart tra...
Next Document:  Ten years' evaluation of diet, anthropometry, and physical exercise adherence after islet allotransp...