Document Detail


Beyond heart rate variability: vagal regulation of allostatic systems.
MedLine Citation:
PMID:  17192580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The autonomic nervous system (ANS) plays a role in a wide range of somatic and mental diseases. Whereas the role of the ANS in the regulation of the cardiovascular system seems evident, its role in the regulation of other systems associated with allostasis is less clear. Using a model of neurovisceral integration we describe how the ANS and parasympathetic tone in particular may be associated with the regulation of allostatic systems associated with glucose regulation, hypothalamic-pituitary-adrenal (HPA) axis function, and inflammatory processes. Decreased vagal function and heart rate variability (HRV) were shown to be associated with increased fasting glucose and hemoglobin A1c levels, increased overnight urinary cortisol, and increased proinflammatory cytokines and acute-phase proteins. All of these factors have been associated with increased allostatic load and poor health. Thus, vagal activity appears to play an inhibitory function in the regulation of allostatic systems. The prefrontal cortex and the amygdala are important central nervous system structures linked to the regulation of these allostatic systems via the vagus nerve. Finally, the identification of this neurovisceral regulatory system may help to illuminate the pathway via which psychosocial factors may influence health and disease.
Authors:
Julian F Thayer; Esther Sternberg
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1088     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-28     Completed Date:  2007-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-72     Citation Subset:  IM    
Affiliation:
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA. Thayer.39@osu.edu
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MeSH Terms
Descriptor/Qualifier:
Autonomic Nervous System / physiology*
Heart Rate / physiology*
Humans
Inflammation / physiopathology*
Neuroimmunomodulation / physiology
Neurosecretory Systems / physiology*
Vagus Nerve / physiology*

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