Document Detail


Beyond fast food and slow motion: weighty contributors to the obesity epidemic.
MedLine Citation:
PMID:  22183119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Decreased physical activity and marketing-driven increased consumption of "junk" food, dubbed "The Big Two", are generally regarded as the most important contributors to the obesity epidemic. However, the full picture contains many more pieces of the puzzle. We address several additional issues and review current clinical developments in obesity research. In spite of dramatic advancements in our understanding of the adipose organ and its endocrine and immune products, the ultimate causes of the obesity epidemic remain elusive. Treatment is plagued by poor adherence to life style modifications, and available pharmacological options are marginally effective, often also associated with major side effects. Surgical treatments, albeit effective in decreasing body weight, are invasive and expensive. Thus, our approaches to finding the causes, improving the existing treatments, and inventing novel therapies must be manifold.
Authors:
G Cizza; K I Rother
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-12-15
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  35     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-11     Completed Date:  2012-08-08     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  236-42     Citation Subset:  IM    
Affiliation:
Section on Neuroendocrinology of Obesity, NIDDK, Clinical Center, NIH, DHHS, Bethesda, MD, USA. cizzag@intra.niddk.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Body Weight / physiology
Epidemics
Fast Foods / adverse effects*,  statistics & numerical data
Feeding Behavior / physiology
Humans
Models, Biological
Motion
Motor Activity / physiology*
Obesity / epidemiology*,  etiology*
Risk Factors
Sedentary Lifestyle
Grant Support
ID/Acronym/Agency:
Z99 DK999999/DK/NIDDK NIH HHS; ZIA DK047049-04/DK/NIDDK NIH HHS; ZIA DK075052-01/DK/NIDDK NIH HHS; ZIA DK075053-01/DK/NIDDK NIH HHS
Comments/Corrections

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