Document Detail

Beyond dyssynchrony in cardiac resynchronisation therapy.
MedLine Citation:
PMID:  18625794     Owner:  NLM     Status:  MEDLINE    
Cardiac resynchronisation therapy (CRT) in the form of biventricular pacing has emerged as a therapeutic option for patients with refractory heart failure. Patient selection and optimisation for CRT is based on the measurement of electromechanical ventricular dyssynchrony by electrocardiogram and echocardiographic techniques. The final common pathway for raising cardiac output on exertion is to minimise isovolumic time and maximise useful diastolic filling time, but correction of dyssynchrony alone may not lead to global improvement in about one-third of patients. Insights into pressure relations and abnormal timing, as well as clinical management, may hold the key to optimum outcome.
R Chung; R Sutton; M Y Henein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  94     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  991-4     Citation Subset:  AIM; IM    
Royal Brompton Hospital, London, UK.
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MeSH Terms
Cardiac Pacing, Artificial / methods*
Heart Failure / complications,  therapy*
Patient Selection
Treatment Failure
Ventricular Dysfunction, Left / etiology,  therapy,  ultrasonography

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