Document Detail


Beyond cervical length: emerging technologies for assessing the pregnant cervix.
MedLine Citation:
PMID:  22717270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spontaneous preterm birth is a heterogeneous phenotype. A multitude of pathophysiologic pathways culminate in the final common denominator of cervical softening, shortening, and dilation that leads to preterm birth. A precise description of specific microstructural changes to the cervix is imperative if we are to identify the causative upstream molecular processes and resultant biomechanical events that are associated with each unique pathway. Currently, however, we have no reliable clinical tools for quantitative and objective evaluation, which likely contributes to the reason the singleton spontaneous preterm birth rate has not changed appreciably in >100 years. Fortunately, promising techniques to evaluate tissue hydration, collagen structure, and/or tissue elasticity are emerging. These will add to the body of knowledge about the cervix and facilitate the coordination of molecular studies and ultimately lead to novel approaches to preterm birth prediction and, finally, prevention.
Authors:
Helen Feltovich; Timothy J Hall; Vincenzo Berghella
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-05-23
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-01-22     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-54     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics & Gynecology, Intermountain Healthcare, Provo, UT 84604, USA. hfeltovich@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cervical Length Measurement*
Cervix Uteri / ultrasonography,  ultrastructure*
Elasticity Imaging Techniques
Electric Impedance
Female
Humans
Mice
Pregnancy
Premature Birth / diagnosis*,  pathology,  ultrasonography
Rats
Grant Support
ID/Acronym/Agency:
R21 HD061896/HD/NICHD NIH HHS; R21 HD063031/HD/NICHD NIH HHS; R21HD061896/HD/NICHD NIH HHS; R21HD063031/HD/NICHD NIH HHS
Comments/Corrections

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