| Beyond cervical length: emerging technologies for assessing the pregnant cervix. | |
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MedLine Citation:
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PMID: 22717270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous preterm birth is a heterogeneous phenotype. A multitude of pathophysiologic pathways culminate in the final common denominator of cervical softening, shortening, and dilation that leads to preterm birth. A precise description of specific microstructural changes to the cervix is imperative if we are to identify the causative upstream molecular processes and resultant biomechanical events that are associated with each unique pathway. Currently, however, we have no reliable clinical tools for quantitative and objective evaluation, which likely contributes to the reason the singleton spontaneous preterm birth rate has not changed appreciably in >100 years. Fortunately, promising techniques to evaluate tissue hydration, collagen structure, and/or tissue elasticity are emerging. These will add to the body of knowledge about the cervix and facilitate the coordination of molecular studies and ultimately lead to novel approaches to preterm birth prediction and, finally, prevention. |
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Authors:
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Helen Feltovich; Timothy J Hall; Vincenzo Berghella |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-05-23 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 207 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-30 Completed Date: 2013-01-22 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 345-54 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics & Gynecology, Intermountain Healthcare, Provo, UT 84604, USA. hfeltovich@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cervical Length Measurement* Cervix Uteri / ultrasonography, ultrastructure* Elasticity Imaging Techniques Electric Impedance Female Humans Mice Pregnancy Premature Birth / diagnosis*, pathology, ultrasonography Rats |
| Grant Support | |
ID/Acronym/Agency:
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R21 HD061896/HD/NICHD NIH HHS; R21 HD063031/HD/NICHD NIH HHS; R21HD061896/HD/NICHD NIH HHS; R21HD063031/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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