Document Detail

Beyond blood pressure control. Effect of antihypertensive therapy on cardiovascular risk factors.
MedLine Citation:
PMID:  3056446     Owner:  NLM     Status:  MEDLINE    
Mild hypertension accounts for approximately 60% of the mortality associated with high blood pressure. In addition to hypertension, other major cardiovascular risk factors include left ventricular hypertrophy (LVH), dyslipoproteinemia, and glucose intolerance. Thus, the effects of agents used to treat hypertension on these risk factors are of considerable importance. Large therapeutic intervention trials have shown that while adequate treatment of mild hypertension significantly and consistently reduces all-cause mortality as well as the risk of stroke and congestive heart failure, an anticipated reduction in coronary heart disease (CHD) has not been demonstrated. It is possible adverse metabolic side effects (hypercholesterolemia, hyperglycemia, hypokalemia) of widely used agents, such as diuretics and beta-blockers may be partially offsetting the beneficial effects of blood pressure reduction, with the net result being a failure of these agents to reduce the risk of CHD. Angiotensin-converting enzyme inhibitors (ACEIs) and calcium channel blockers do not produce these adverse metabolic derangements. The use of antihypertensive agents that have favorable or neutral metabolic effects should further reduce the risk of cardiovascular morbidity and mortality attributable to high blood pressure, including CHD.
M H Maxwell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of hypertension     Volume:  1     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-28     Completed Date:  1988-12-28     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  366S-371S     Citation Subset:  IM    
UCLA School of Medicine, Los Angeles, CA 90024.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Coronary Disease / etiology*
Hypertension / complications*,  drug therapy
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents

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